Research

Ongoing Projects:

- Novel approaches for diabetes management by a combination of

kinase inhibition and stem cell application.

- Restoration of beta-cell function via inhibition of diabetic kinome.

The worldwide incidence of Diabetes, which is directly associated with the rapid rise of obesity, cancer, cardiovascular and Alzheimer's disease, has been rising exponentially for the past few decades and still without a cure, but only with temporary treatments. The international collaborative research project designed by our laboratory will allow the advancement of science towards an efficient therapy against this devastating disease. It will be achieved by combining advanced fields from protein crystallography and chemical synthesis for the final development of kinase inhibitors to restore beta-cell function in the diabetic pancreas; patient-derived induced pluripotent stem cells (iPSCs) to regenerate the pancreatic beta-cell mass; and nanodelivery systems to enhance the delivery and functionality of both drug and cells, all synchronized for an effective and personalized cure for Diabetes.

Protein Crystallography

We will expand the screening for novel inhibitors, evaluate binding modes of novel molecules through biophysical and biological characterization by NMR and X-ray crystallography and select effective kinase inhibitors.

Nanotechnology

Nanotechnology offers specific targeting, enhancing migration, homing, proliferation, and commitment of stem cells. Nanocarriers containing the kinase inhibitor and transcription factors will provide absolute control over delivery and guided release.

Stem Cells

Here, the objective is to establish robust protocols for the generation of safe iPSC-derived beta-cells and evaluate the regenerative potential to create the basis for a personalized cure for diabetes by regeneration of pancreatic islets.

Funding